PATCHMASTER NEXT serves as a comprehensive toolkit designed for conducting electrophysiological and electrochemical experiments with ease. This advanced software offers multi-channel stimulation and data acquisition, complete with capabilities for both online and offline analysis. Specifically tailored for amplifiers, PATCHMASTER NEXT excels in managing devices like the EPC 10 USB amplifiers, which include Single, Double, Triple, and Quadro models. Additionally, it allows for the integration and control of auxiliary components such as temperature controllers, perfusion systems, and other third-party equipment. Users will quickly notice a significant alteration in the graphical user interface when they first use PATCHMASTER NEXT, which aims to enhance user experience. The revamped interface, combined with a familiar workflow, is designed to ease the transition for both newcomers and seasoned PATCHMASTER users alike. As an evolution of the original PATCHMASTER software, PATCHMASTER NEXT elevates the functionality and performance of its renowned patch clamp software to new heights. Ultimately, this development signifies a major advancement in the capabilities available for researchers in the field.